CISMMWelcome to the Center for Computer Integrated Systems for Microscopy and Manipulation (CISMM) at UNC Chapel Hill, funded by the National Institutes of Health and National Institute of Biomedical Imaging and Bioengineering through award number 5- P4. EB0. 02. 02. 5. В CISMM develops force technologies applicable over a wide range of biological settings, from the single molecule to the tissue, applied to cancer. Complementing this tool set is the development of a wide range of analysis and visualization tools, in the desktop and in virtual environments, that are being applied to domains from the molecular models of cellular structure, to flows in the three dimensional mesh of blood clots, to a dynamic atlas of geometry and growth in pediatric airways. Latest News. Chromo. Shake is chosen to be the cover image of the journal Molecular Biology of the Cell in the January 2. It is a three- dimensional simulator designed to find the thermodynamically favored states for given chromosome geometries, to a geometric model based on experimentally determined characteristics of the budding yeast centromere. This movie shows a side- view of the nucleus of a SKOV cell, an ovarian cancer cell line, with the DNA labeled with a red fluorescent nucleic acid stain and and membrane stain in same channel, as captured with Vertical Light Sheet Sideways Microscopy (VLSSM).
Over the course of the movie an Atomic Force Microscope (AFM) cantilever with 5. Ојm bead tip deforms the nucleus with 1. N of force. The movie was recorded at 5. AFM. For more information on VLSSM follow this link : http: //cismm.
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Technology Research and Development (TRD)В В TRD 1: Force Microscope Technologies. TRD 2: Molecular Imaging Tools. TRD 3 (sunsetted): Biomedical Image Analysis. Collaborations form the heart of our resource. Their influence has grown to 1. UNC. Collaborators are organized as Collaboration Clusters: Cell Mechanics Cluster. Lung Cluster. Thrombosis Cluster.
Service, Training, and Dissemination. This Resource prides itself on building computer- based tools for microscopy and force measurements to serve the needs of scientists working on the frontiers of knowledge.
Our goals are to support visiting scientists, to support Resource- developed hardware/software systems delivered outside the Resource, to support and enhance the research of users who come to our laboratories at UNC. Service: Come use our resources, either by visiting us at UNC, getting our hardware, or through our free software. Dissemination: download our software, learn about our work through our publications. Training: Come learn about forces in biology through our annual Carolina Workshop on Forces in Biology hosted at UNC May 1. Come Use Our Facilities.
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As an NIH National Research Resource we provide access to our unique facilities to researchers doing related work. Click here to learn more about using this facility.
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